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Studies in rats and beagle dogs have shown a rapid elimination half-life of less than 30 minutes after intravenous administration

The expression of NOX4, ACSL4 and levels of ROS and iron are increased in the spinal cord of rats subjected to spared nerve injury, while the expression of GPX4 is decreased

Audrito, V

The exact half-life in humans is not fully confirmed, detection windows remain uncertain, and long-term safety data is still lacking

By comparison, the rate constant for thiol oxidation by superoxide (O 2 ) has been estimated to be in the range of 100 M 1 s 1 ( 2 -concentration is restricted by superoxide dismutase to approximately 10 10 M ( in vitro to O 2 -that was steadily produced by xanthine oxidase (2 M/min over a period of 4 h)