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The variability in total IGF-I may be due, in part, to major changes in selective IGFBPs during the post-bariatric surgery period, i.e

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When excessive iron ions accumulate in cells, the resulting free Fe + triggers Fenton reactions that generate ROS

Water molecules attack peptide bonds, cleaving the amino acid chain into smaller fragments

For instance, manifestation of radiation toxicity at the cellular level involves simultaneous activation of various pro-survival and cytotoxic pathways in a ROS-dependent (indirect effect of radiation) and independent (direct effect of radiation) manner [37, 40, 100]