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The honest summary is that long-term human safety data is missing and the angiogenesis mechanism is an unresolved theoretical concern
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Tailored dietary interventions, regular monitoring, and interdisciplinary collaboration can significantly enhance nutritional status and overall quality of life[73]
Given that both diet composition and adiposity can each substantially impact the gut microflora in obese mice 24 , we conducted a secondary endpoint study using animals given the same series of diets to test the hypothesis that NNMTi treatment combined with LD, but not LD alone, shifts the cecal microbiome profile of obese animals to be similar to age-matched LD controls that were never given a high-fat diet
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