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studied cytokine mRNA expression in intrathyroidal T cells and found increased expression of IFN-gamma, IL-2 and CD25, which are Th1-related cytokines(12) in Hashimoto's thyroiditis

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Collectively, these results demonstrated that the activation of the NRF2/SLC7A11/GSH axis serves as a protective mechanism, shielding ATC cells from KU-57788-induced cytotoxicity