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A true cold-chain commitment means the vendor specifies the maximum transit temperature, uses gel packs rated for 48 to 72 hours, and ships Monday through Wednesday to avoid weekend delays at distribution centers

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For topical administration routes, including dermal and ocular delivery, hydrogels and nanogels are often limited by suboptimal skin permeability, poor adhesiveness, and challenges in large-scale manufacturing (Grillo et al., 2019

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