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The observed decrease in GPx4 activity after TBI, along with these findings, suggests that the System Xc/GSH/GPX4 pathway plays an important role in the activation of ferroptosis following TBI (Figure 3D

also known as N -hexanoic-Tyr-Ile-(6) aminohexanoic amide) is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met