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Interestingly, hyperglycemia has been reported to induce an increased intestinal permeability through GLUT2-dependent mechanisms and the alteration of tight junction cohesion, thus creating a leaky gut state [53]

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Limited, well-timed use around surgical repair, embryo transfer, or ovulation could still exploit the pro-repair and angiogenic effects while minimizing systemic exposure

48 , W449W454 (2020)

doi:10.1534/genetics.107.075838