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In terms of nicotine delivery from IQOS, a randomized crossover study showed that the nicotine delivery rate was similar between IQOS and CS with lower plasma nicotine peak after IQOS use (70% of CS peak) 87 , and another study reported a similar pharmacokinetic profile of nicotine from IQOS and CS with similar user satisfaction 88

In a Smokeless tobacco In a 2023 study, researchers aimed to examine the influence of smoking habits, exposure to snuff, and passive smoking on MS progression

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However, the study also noted that there was significant substitution with adolescents switching to either menthol cigarettes or other flavored combustible products like cigars, indicating that the public health impact would have been much stronger had the flavor ban applied to all combustible products as well as menthol cigarettes

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