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A thorough pre-treatment evaluation supports safer, more targeted therapy

In a study using cultured rat hippocampal neurons, pre-treatment of nerve cells with GLP-1 resulted in a weakened Ca 2+ response to glutamate and weakened membrane depolarization (46)

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doi: 10.3390/cells9071667 133 PanYLinSPanNChengSYaoJLiangPet al

As an important transcription factor, Nrf2 can not only regulate SLC7A11 transcription, but also up-regulate the expression of GSS and GCLC, which are key rate-limiting enzymes for GSH synthesis (Sun et al., 2016a