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If you're taking semaglutide alongside other drugs that rely on CYP3A4 metabolism, grapefruit consumption could amplify their effects unpredictably
Compared to bupropion-naltrexone, GLP-1 agonists were associated with a: 9.09 times higher risk of pancreatitis , or inflammation of the pancreas, which can cause severe abdominal pain and, in some cases, require hospitalization and surgery
Endocrinology and Metabolism, 281(5), E1095-1100
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However, in a more recent randomized, placebo-controlled study in 102 subjects, daily supplementation with 600 mg of lipoic acid (+/- 800 mg of vitamin E [-tocopherol]) for 16 weeks had no effect on fasting blood glucose, fasting blood insulin, or a measure of insulin resistance called the homeostatic model assessment of insulin resistance (HOMA-IR) index (59)
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