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47,48 ), it follows that the GDH1-KG axis controls YBX1AMPK-dependent energy sensing only in cellular contexts where GDH1 is a major dictator of intracellular -KG abundance

A healthy, diverse microbiome is fundamental to mucosal integrity it produces the short-chain fatty acids that fuel the gut lining, crowds out pathogenic overgrowths, and maintains the tight junction proteins that regulate intestinal permeability

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