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The activation of the PDGF/PDGFR pathway drives the proliferation and migration of HSC and promotes ECM deposition, all of which advance the course of fibrosis ( SalB , and SalB relieves HF by inhibiting the PDGFR- signaling pathway and inducing HSC apoptosis, and inflammatory reaction of HSC ( 2.1.3 Hedgehog The hedgehog (Hh) pathway is thought to be connected with the level of fibrosis and has the capacity to activate HSC (Zhao et al., 2016)

Neither insurance-billed clinics nor branded-pharmacy routes include this stratification step

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