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- Art Little Theatres, Variety, October 19, 1927, pg 27

While nicotine can have mild cardiovascular effects, such as increasing heart rate, the major causes of smoking-related illness come from toxic smoke exposure rather than nicotine itself

2 Definitions and Tobacco Products Smoking is a real chronic disorder related to the intermittent and compulsive consumption of an exogenous substance, sustained by the development of an addiction status, which is mainly due to nicotine [11]

With this, the habitual consumption of cigarettes and other forms of inhalation consumption has become a public health problem worldwide