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Analyses of changes after randomization used a landmark approach, beginning at week 20 and excluding events before that point, and were observational rather than causal

They can be activated by microbe-related antigens like peptidoglycan, lipoteichoic acid, and LPS in the intestine, thereby initiating downstream reactions by recruiting signaling molecules through the myeloid differentiation factor 88 (MyD88) pathway or MyD88-independent signal transduction (53)

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Weight stability : Some patients maintain stable weight on lower doses, though systematic evidence for doses below 1.7 mg remains limited

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