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[34] One study's authors warned against the potential harm of excessive regulation and advised health professionals to consider advising smokers who are reluctant to quit by other methods to switch to e-cigarettes as a safer alternative to smoking

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Women, on average, smoke fewer cigarettes per day than men, and in many countries the smoking epidemic in women has been much shorter in duration for womenboth these factors mean that the RRR could actually be even higher for women

Nicotine is highly addictive and can negatively affect youth brain development, which continues into a persons mid-20s