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In the phase 2 trial, the 8mg group achieved approximately 17.3% weight reduction at 24 weeks, a rate of loss that would not be possible without profound appetite suppression driving significant caloric deficit

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The advantages of GLP-1 agonists include substantial clinical trial data supporting their efficacy and safety, FDA approval for weight management in certain populations, proven results with many users losing 15-20% or more of body weight, and effects on appetite that make caloric restriction feel natural

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doi: 10.3390/nu14020355, 129