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The combination doesn't create new known risks, but a few considerations are worth flagging

Micronutrient adequacy becomes challenging when appetite is suppressed

Four name-brand medications are FDA-approved specifically for weight loss: Wegovy (semaglutide), Zepbound (tirzepatide), Saxenda (liraglutide), and Foundayo (orforglipron)

Clinicians bear direct responsibility for the dosing decision

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