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doi: 10.1016/j.cbi.2010.07.010 61 SteinertJRAmalH

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Reduced insulin sensitivity, with increases in fasting blood glucose and HbA1c relative to placebo over 12 months in the same controlled trial, a concern for anyone with existing metabolic risk

Approaches that inhibit glucose transporters (such as GLUT1 or GLUT3) offer upstream control of nutrient supply but often face compensatory upregulation of alternative transporters and may trigger systemic toxicity due to the essential role of glucose uptake in normal tissues

Folate is needed for the spinal cord to develop correctly