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Table of Contents Introduction Dipeptidyl Peptidase-4 (DPP-4) Inhibitors , commonly referred to as gliptins , are oral antidiabetic drugs that enhance the action of incretin hormones , especially GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide)

These compounds penetrate the BBB in sufficient quantity to facilitate memory consolidation and retrieval in aged rats, and the scopolamine-induced amnesic rat model of AD, as measured employing the Morris water maze task of spatial memory [80]

10.1038/nm.3009 40 FinkelsteinE

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