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The histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) alleviates depression-like behavior and normalizes epigenetic changes in the hippocampus during ethanol withdrawal

Pruritus, the most unbearable symptom in cholestasis, is probably induced by the stimulation of nonmyelinated subepidermal free nerve ends because of increased levels of serum BAs [13]

doi: 10.1038/nrg3182 12 ColladoM

When this shows up, really digging into the patients history for what may be inciting these deficiencies is necessary

Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling