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This is because the parameters of intrinsic fluorescence (particularly those of tryptophan (Trp) fluorescence), such as intensity, lifetime, anisotropy, and peak emission wavelength, are highly sensitive to the local environment and provides valuable, label-free insights into protein structure, dynamics, and conformational changes

However, the correlation of 5-HIAA with UA and Xan appear to be much weaker in the BL and 4w groups

Solubility of Naproxen and indomethacin in supercritical carbon dioxide/ethyl acetate mixtures

However, MMA levels can be elevated in those with thyroid and kidney conditions, which limits the tests specificity (9, 10)

However, various limitations of these two biomarkers, including low sensitivity and specificity, delayed rise in plasma because of functional reserve, and extrarenal clearance, demand for novel renal biomarkers to early detect and monitor drug-induced nephrotoxicity with high specificity and sensitivity