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Preclinical data support the therapeutic potential of FDCA in ischemic stroke, and small-scale clinical trials have confirmed its safety and partial efficacy, providing a foundation for subsequent large-scale applications (229)

this suggests that glutamine inhibitors such as DON could deplete the ECM and allow infiltration of tumors by CD8(+) T cells 151

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Meanwhile, RT-PCR and western bolt analysis revealed that the ER stress related genes such as GRP78, ATF4, CHOP, XBP1 were more highly expressed in the mice e lack of 5-HT (Figure 6B and 6C)

Puts et al., 2017