[cited 2023 June 29] 34
The similarity of the direction and magnitude of the effect estimates between individual trials, the number of trials that contributed data, mostly to within-trial comparisons, and the statistical analyses implemented support the credibility of the conclusions favouring use of SGLT2i or GLP-1 RA in individuals with compelling indications independent of the use of metformin
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Moreover, null or inconsistent findings in some mechanistic trials, including absent changes in certain satiety hormones or mixed reward-response patterns, underscore the complexity of these pathways