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Hypersensitivity reactions may be due to the various vehicles present in the different ketoconazole formulations

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Skipping titration steps or increasing doses too quickly is the most common reason patients experience more intense side effects than necessary

In vitro studies have demonstrated that the addition of 50 M CoQ10 to the culture medium resulted in increased expression of Bcl2 and Sirt1 in cumulus cells, and a positive impact on the reduction of ROS, maturation rate, and first polar body extrusion was enhanced from 48.9% to 75.7% by the addition of CoQ10 to the culture medium (Lee et al., 2022)

Nature Med 28(9):1956-1964