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Unlike existing SGLT2 inhibitors, which solely reduce blood glucose levels by blocking the reabsorption of glucose in the renal tubules, celastrol can exert its effects through multiple pathways, such as anti-inflammation, anti-oxidation, anti-fibrosis, and the regulation of ferroptosis and lipid metabolism

Ren Fail (2018) 40(1):4927

Because not everyone will be able to convert glutathione effectively from NAC, the best way to support glutathione is to supplement with it in a highly absorbable form

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Rather than focusing solely on therapeutic efficacy, this work integrates material design, localized drug delivery, and biological evaluation to explore a rectally administered strategy aimed at enhancing local radioprotection while minimizing systemic exposure