weight loss with glp-1 agonists Which Agonist is Best for Loss? What Is GLP-1 and Why

Tirzepatide (Mounjaro and Zepbound) produces larger total weight loss than semaglutide on average, which means larger absolute muscle loss in numbers, even if the proportional loss is similar

Gut (1996) 38:9169

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Tirzepatide functions as an imbalanced dual agonist, characterised by a molecular structure exhibiting a markedly higher affinity for the GIP receptor than the GLP-1 receptor

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