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This boost in GLP-1 activity can lead to weight loss through several mechanisms: slowing the rate at which your stomach empties to reduce hunger and minimize the amount of glucose spikes, decreasing glucagon formation and the resultant glucose in the bloodstream, and stimulating insulin release from the pancreas when blood sugar levels are high, such as after meals (3, 4, 5)

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Diabetes and hypertension also require ongoing medication

These medications mimic the incretin hormone GLP-1, which signals the pancreas to release insulin after eating, slows gastric emptying, and reduces appetite through brain signaling

Tolerability in the MASH trial mirrored the obesity data: nausea (66% vs