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PMID: 35902457

An iRGD-conjugated prodrug micelle with blood-brain-barrier penetrability for anti-glioma therapy

Mental Health Concerns There have been reports suggesting a possible association between GLP-1 usage and mental health issues including depression and suicidal thoughts

Dark amber urine or no urine output for 8 or more hours, dizziness or near-syncope when standing, heart rate consistently above 100 beats per minute at rest, dry mucous membranes with absent skin turgor

a multivitamin supplement is recommended, taken at bedtime or at least 2 hours before or after an orlistat dose Orlistat should be skipped if a meal is fat-free or a meal is missed Important interactions with orlistat include: Ciclosporin : avoid concomitant use (reduced ciclosporin absorption) Warfarin and other anticoagulants : monitor INR closely, as orlistat may affect vitamin K absorption Levothyroxine : separate doses by at least 4 hours and monitor thyroid function Antiepileptics (e.g., valproate, lamotrigine) and some antiretrovirals : reduced absorption possible