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Based on current advancements in oxidative stress research in breast cancer, we propose several innovative therapeutic approaches targeting the ROSPCD network for future development: (1) Oxidative stress-directed small-molecule drugs: Natural compounds such as curcumin can induce apoptosis by triggering mitochondrial ROS bursts and DNA damage while enhancing ferroptosis sensitivity through GPX4 inhibition

Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice

These alterations coincide with elevated lipid peroxidation levels (221)

Jiang HR, Milovanovi M, Allan D, Niedbala W, Besnard AG, Fukada SY, et al